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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2016  |  Volume : 27  |  Issue : 4  |  Page : 839-840
Remarks about the study on causes of chronic kidney disease in Egyptian children

Department of Pediatrics, Al-Kindy College of Medicine, Baghdad University, Baghdad, Iraq

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Date of Web Publication5-Jul-2016

How to cite this article:
Al-Mendalawi MD. Remarks about the study on causes of chronic kidney disease in Egyptian children. Saudi J Kidney Dis Transpl 2016;27:839-40

How to cite this URL:
Al-Mendalawi MD. Remarks about the study on causes of chronic kidney disease in Egyptian children. Saudi J Kidney Dis Transpl [serial online] 2016 [cited 2022 Aug 7];27:839-40. Available from: https://www.sjkdt.org/text.asp?2016/27/4/839/185302
To the Editor,

I read with interest the study by Safouh et al [1] on the causes of chronic kidney diseases (CKDs) in Egyptian children. It is obvious that early identification of congenital urological anomalies (CUA) in children and implementation of appropriate therapy are essential to prevent the progression to end-stage renal diseases (ESRDs). Safouh et al [1] addressed that CUA comprised 46% of the underlying etiology in their studied patients with CKDs. Such prevalence is less than that reported in Kuwait (61.9%) [2] but equal to that reported in Saudi Arabia (45.3%) [3] and Jordan (42.1%). [4] However, it is more than that reported in Iraq (36%) [5] and Sudan (17.5%). [6] Despite that regional variation, CUA still represents an important avoidable cause of pediatric CKDs, particularly in those under the age of five years, and efforts should be spent to identify factors contributing to it. I presume that consanguineous marriage (CM) represents an important cause of the spike in the CUA prevalence among the Arabian pediatric population. This is based on the observation that the practice of CM has been the culturally preferred form of marriage in most Arab and the Middle Eastern countries. Moreover, it has been found that consanguineous couples have a higher risk of having children with various congenital malformations, including CUA. The risk is increased by a factor 2-2.5. [7] I presume that in order to minimize future risk of ESRDs, certain actions are needed to contain a further surge in CUA prevalence among the Arabian pediatric population, including Egypt. This could be plausibly achieved by the following measures: (1) as recommended by Safouh et al, [1] establishing an accurate national registration system that provides detailed information concerning the prevalence, causes, and overall outcomes of renal functional impairment deems essential. (2) Awareness of public ought to be increased through various means, including premarital counseling on the devastating aftermaths of CM and potentially increasing the risk of various congenital malformations, including CUA. (3) There is a need to stress the importance of prenatal ultrasonography in antenatal health-care visits as an effective means to detect fetal malformative uropathies. This might be supplemented whenever feasible by magnetic resonance imaging to refine the diagnosis of suspected renal anomalies detected during screening ultrasonography. [8]

Conflict of interest: None declared.

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   References Top

Safouh H, Fadel F, Essam R, Salah A, Bekhet A. Causes of chronic kidney disease in Egyptian children. Saudi J Kidney Dis Transpl 2015;26:806-9.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
Al-Eisa A, Naseef M, Al-Hamad N, Pinto R, Al-Shimeri N, Tahmaz M. Chronic renal failure in Kuwaiti children: An eight-year experience. Pediatr Nephrol 2005;20:1781-5.  Back to cited text no. 2
Al-Ghwery S, Al-Asmari A. Chronic renal failure among children in Riyadh Military Hospital, Riyadh, Saudi Arabia. Saudi J Kidney Dis Transpl 2004;15:75-8.  Back to cited text no. 3
[PUBMED]  Medknow Journal  
Hamed RM. The spectrum of chronic renal failure among Jordanian children. J Nephrol 2002;15:130-5.  Back to cited text no. 4
Ahmed NF, Hussain HH. Chronic renal failure in children admitted to children welfare teaching hospital. Iraqi Postgrad Med J 2008;7:12-7.  Back to cited text no. 5
Ali el-TM, Abdelraheem MB, Mohamed RM, Hassan EG, Watson AR. Chronic renal failure in Sudanese children: Aetiology and outcomes. Pediatr Nephrol 2009;24:349-53.  Back to cited text no. 6
Søgaard M, Vedsted-Jakobsen A. Consanguinity and congenital abnormalities. Ugeskr Laeger 2003;165:1851-5.  Back to cited text no. 7
Abdelazim IA, Belal MM. The role of magnetic resonance imaging in refining the diagnosis of suspected fetal renal anomalies. J Turk Ger Gynecol Assoc 2013;14:6-10.  Back to cited text no. 8

Correspondence Address:
Prof. Mahmood Dhahir Al-Mendalawi
Department of Pediatrics, Al-Kindy College of Medicine, Baghdad University, Baghdad
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-2442.185302

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