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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2017  |  Volume : 28  |  Issue : 1  |  Page : 186-187
Zika virus infection: What should we know as nephrologists?

1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Department of Medicine, Faculty of Medicine, University of Nis, Nis, Serbia; Department of Tropical Medicine, Hainan Medical University, Haikou, China

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Date of Web Publication12-Jan-2017

How to cite this article:
Joob B, Wiwanitkit V. Zika virus infection: What should we know as nephrologists?. Saudi J Kidney Dis Transpl 2017;28:186-7

How to cite this URL:
Joob B, Wiwanitkit V. Zika virus infection: What should we know as nephrologists?. Saudi J Kidney Dis Transpl [serial online] 2017 [cited 2023 Feb 4];28:186-7. Available from: https://www.sjkdt.org/text.asp?2017/28/1/186/198274
To the Editor,

Emerging infectious diseases usually bring public health problems. The Zika virus infection is a new arboviral infection that is declared by the World Health Organization as a new public health threat.[1] This infection can cause acute febrile illness.[2] ,[3] It manifests as a dengue-like acute viral hemorrhagic fever.[2] ,[3] In addi-tion, it also induces fetal abnormalities if it occurs during pregnancy.[2] ,[3] To nephrologists, it is an important concern since it may cause renal problems such as the other arboviral infection, dengue.

There are many reports on the clinical presentation of the Zika virus infection. However, based on our present knowledge, there are still no reports on the renal presentation in Zika virus infection.[4] ,[5] Although it is confirmed that the virus passes through the kidney and is excreted in the urine,[6] ,[7] there is still no report on renal abnormalities among patients with Zika virus infection. A recent report investigating renal function tests in Zika virus infection showed normal results.[5] Another report from China on a patient with the Zika virus infection[5] mentioned the presence of bilateral renal calculi on renal imaging. This may be only an incidental finding. However, this finding is interesting and should be further studied. Focusing on renal pathology, autopsy studies have not shown the presence of the virus in kidney tissue.[8] ,[9] However, the problem has not been evaluated in animal models.[10] Another interesting concern is on the effect of Zika virus infection in renal transplant patients. As a new infection, there is limited knowledge on the relationship between Zika virus and transplantation-related transmission. Chan et al, recently, studied the possibility of transplantation-related transmission of the Zika virus.[4] In fact, dengue, a similar virus, has already been confirmed to have transplantationrelated transmission.[11]

We conclude that presently, there is still no evidence of renal problems in humans infected with the Zika virus. However, the topic needs further study by the nephrologists.

Conflict of interest: None declared.

   References Top

Joob B, Wiwanitkit V. Zika virus infection and dengue: A new problem in diagnosis in a dengue-endemic area. Ann Trop Med Public Health 2015;8:145-6.  Back to cited text no. 1
  Medknow Journal  
Wiwanitkit S, Wiwanitkit V. Acute viral hemorrhage disease: A summary on new viruses. J Acute Dis 2015;4:277-9.  Back to cited text no. 2
Gulland A. Zika virus is a global public health emergency, declares WHO. BMJ 2016;352: i657.  Back to cited text no. 3
Chan JF, Choi GK, Yip CC, Cheng VC, Yuen KY. Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease. J Infect 2016;72:507-24.  Back to cited text no. 4
Deng Y, Zeng L, Bao W, Xu P, Zhong G. Experience of integrated traditional Chinese and Western medicine in first case of imported Zika virus disease in China. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2016;28:106-9.  Back to cited text no. 5
Campos Rde M, Cirne-Santos C, Meira GL, et al. Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil. J Clin Virol 2016;77:69- 70.  Back to cited text no. 6
Shinohara K, Kutsuna S, Takasaki T, et al. Zika fever imported from Thailand to Japan, and diagnosed by PCR in the urines. J Travel Med 2016;23. pii: tav011.  Back to cited text no. 7
Sarno M, Sacramento GA, Khouri R, et al. Zika virus infection and stillbirths: A case of hydrops fetalis, hydranencephaly and fetal demise. PLoS Negl Trop Dis 2016;10: e0004517.  Back to cited text no. 8
Mlakar J, Korva M, Tul N, et al. Zika virus associated with microcephaly. N Engl J Med 2016;374:951-8.  Back to cited text no. 9
Bell TM, Field EJ, Narang HK. Zika virus infection of the central nervous system of mice. Arch Gesamte Virusforsch 1971;35:183- 93.  Back to cited text no. 10
Wiwanitkit V. Unusual mode of transmission of dengue. J Infect Dev Ctries 2009;4:51-4.  Back to cited text no. 11

Correspondence Address:
Beuy Joob
Sanitation 1 Medical Academic Center, Bangkok, Thailand

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-2442.198274

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