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| Year : 2017 | Volume
: 28
| Issue : 3 | Page : 664-665 |
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| The role of hypercalciuria in pathogenesis of recurrent abdominal pain |
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Majid Malaki
Pediatric Nephrology Ward, Sevom-e-Shaban Hospital, Tehran, Iran
Click here for correspondence address and email
| Date of Web Publication | 18-May-2017 |
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How to cite this article:
Malaki M. The role of hypercalciuria in pathogenesis of recurrent abdominal pain. Saudi J Kidney Dis Transpl 2017;28:664-5 |
To the Editor,
More than 100 different conditions may cause recurrent abdominal pain in children but it is almost always attributed to functional disorders.[1] Hypercalciuria is a well-known cause for chronic and recurrent abdominal pain (RAP).[2] Polito et al were not able to find increased incidence of recurrent abdominal pain in children with a history of urolithiasis.[1]
This cross-sectional study tries to find the prevalence of hypercalciuria (random urine calcium to creatinine >0.21) and urolithiasis in 46 children aged over three years with a complaint of chronic abdominal pain for more than two months recurrent abdominal pain. A group and 37 normal age-matched cases selected randomly as control group.
The mean age of the study group was 5.96 ± 2; 52% of whom were female and 48% were male. Kidney ultrasound showed kidney stones or other renal abnormalities in 13%. Hema- turia was seen in 18% of recurrent abdominal pain group and in 5% of control group (P 0.08). Hypercalciuria was found in 13% of recurrent abdominal pain and 12% of control group (P 0.1). There was also no difference in urinary calcium-to-creatinine ratio and recurrent abdominal pain (0.11 ± 0.1 and 0.1 ± 0.08, respectively) (P 0.6).
The incidence of urolithiasis in this study (13%) is significantly higher than seen young population estimated is as much as 1%.[3]
In another study was performed on 124 chil- dren,[4] 42% of cases with recurrent abdominal pain had idiopathic hypercalciuria, whereas renal stones were seen in 11% which made to conclude that idiopathic hypercalciuria should be considered in the differential diagnosis of abdominal pain in children.[4]
In our study, idiopathic hypercalciuria was seen in only 12% and urolithiasis in 13% of the RAP cases. These differences among studies may be backed to different methods, sampling, geographical, and cultural selections.[2]
In conclusion, there are a few studies that evaluate the correlation between hypercal- ciuria, urolithiasis, and recurrent abdominal pain. It seems that RAP in children with hyper- calciuria is not more common significantly than children without hypercalciuria.
Acknowledgment
I dedicate this study to my leader Dr. Mohammad Mosadegh, God bless his soul.
Conflict of interest: None declared.
 References | |  |
| 1. | Polito C, La Manna A, Signoriello G, Marte A. Recurrent abdominal pain in childhood urolithiasis. Pediatrics 2009;124:e1088-94.  [ PUBMED] |
| 2. | Vachvanichsanong P, Malagon M, Moore ES. Recurrent abdominal and flank pain in children with idiopathic hypercalciuria. Acta Paediatr 2001;90:643-8. [ PUBMED] |
| 3. | Remzi D, Cakmak F, Erkan I. A study on the urolithiasis incidence in Turkish school-age children. J Urol 1980;123:608. |
| 4. | Yousefi P, Cyrus A, Dorreh F, Gazerani N, Sedigh HR. Effect of hydrochlorothiazide on reducing recurrent abdominal pain in girls with idiopathic hypercalciuria. J Res Med Sci 2011; 16 Suppl 1:S433-6. [ PUBMED] |
Correspondence Address:
Dr. Majid Malaki
Pediatric Nephrology Ward, Sevom-e-Shaban Hospital, Tehran
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1319-2442.206437
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| This article has been cited by | | 1 |
Hyperuricosuria and hypercalciuria, probable etiologies of functional abdominal pain: A case–control study |
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| Hossein Saneian, Behnoosh Esteki, Maryam Bozorgzad, Fatemeh Famouri, Mehryar Mehrkash, Majid Khademian, Peiman Nasri | | Journal of Research in Medical Sciences. 2022; 27(1): 4 | | [Pubmed] | [DOI] | |
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