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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2018  |  Volume : 29  |  Issue : 2  |  Page : 456-461
Complete remission of nephrotic syndrome secondary to amyloid a amyloidosis in patient with inactive Crohn's disease after treatment by infliximab


Department of Nephrology, Dialysis and Renal Transplantation, Military Training Hospital Mohammed V, Rabat, Morocco

Correspondence Address:
Dr. Mohamed Amine Hamzi
Department of Nephrology, Dialysis and Renal Transplantation, Military Training Hospital Mohammed V, Rabat
Morocco
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-2442.229282

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Secondary amyloidosis Amyloid A (AA) is an infrequent but a severe complication of Crohn's disease (CD). This complication results from the activity of the underlying inflammation disease to form amyloid fibril deposits in tissues. We present a case of a 34-year-old female patient with CD treated by azathioprine with inactive disease for three years and who developed a nephrotic syndrome secondary to AA amyloidosis. The treatment by infliximab for one year leads to a complete remission of the nephrotic syndrome. In this case, this complication occurred while the patient was clinically well, with biological and endoscopic markers showing an inactive or only mildly active disease. Infliximab could be a useful tool for a successful treatment of amyloidosis secondary to CD.


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