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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2018  |  Volume : 29  |  Issue : 5  |  Page : 1240-1244
Distal renal tubular acidosis secondary to vesico-ureteric reflux: A case report with review of literature

1 Department of Pediatrics, Medanta Super-Speciality Hospital, Indore, Madhya Pradesh, India
2 Department of Endocrinology, Medanta Super-Speciality Hospital, Indore, Madhya Pradesh, India
3 Bombay Hospital and Research Center, Indore, Madhya Pradesh, India

Correspondence Address:
Dr. Anjali Bharani
Department of Pediatrics, Medanta Super-Speciality Hospital, Indore, Madhya Pradesh
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DOI: 10.4103/1319-2442.243943

PMID: 30381529

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Vesicoureteric reflux (VUR) is the most common congenital anomaly of the urinary tract that occurs in 30%–50% of children presenting with recurrent urinary tract infections. Long-standing untreated VUR results in renal scarring and hydronephrotic changes ultimately leading to chronic renal failure and arterial hypertension. However, it may also result in diffuse tubulopathy compromising the concentrating capacity of tubules and urinary acidification defects. Renal tubular dysfunction should be considered in all children with VUR presenting with failure to thrive, rickets, bony deformity/pain, hypokalemia, and metabolic acidosis. We report such a case of a 16-year-old male adolescent who presented with rickets, failure to gain weight and height, bony pains, and muscle weakness with a history of VUR. On investigation, he was found to have normal anion gap metabolic acidosis with hypokalemia suggestive of distal renal tubular acidosis. He responded well to oral alkali and potassium replacement therapy.

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