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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2019  |  Volume : 30  |  Issue : 1  |  Page : 268-269
Effect of gold nanoparticle on renal function tests

1 KMT Primary Care Center, Bangkok, Thailand
2 Dr. DY Patil University, Pune, Maharashtra, India

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Date of Submission25-Jun-2018
Date of Acceptance04-Jul-2018
Date of Web Publication26-Feb-2019

How to cite this article:
Yasri S, Wiwanitkit V. Effect of gold nanoparticle on renal function tests. Saudi J Kidney Dis Transpl 2019;30:268-9

How to cite this URL:
Yasri S, Wiwanitkit V. Effect of gold nanoparticle on renal function tests. Saudi J Kidney Dis Transpl [serial online] 2019 [cited 2021 Oct 21];30:268-9. Available from: https://www.sjkdt.org/text.asp?2019/30/1/268/252926

To the Editor,

Nanotechnology has become the new emerging technology at present. The effect of nanosubstance on human health is an interesting issue. The possible effect of nanosubstance on the renal system becomes an interesting issue in clinical nephrology. The effect of the nanosubstance on renal cell was firstly reported by Sereemaspun et al.[1] There are many recently published reports regarding the impaired renal function due to exposure to nanosubstance in animal model studies.[2],[3] Nevertheless, an important issue is the reliability of the renal function tests in cases with existing nanosubstance in blood. Here, the authors present the laboratory observation on the effect of gold nanoparticle on renal function tests. Overall, 100 blood samples were used for analysis. Each sample was separated into two parts; the first part without any manipulation and the second part with adding a droplet of gold nanoparticle solution. The renal function test (blood urea nitrogen and creatinine) was investigated using the same clinical chemistry analyzer in the same ISO certified medical laboratory. The comparison of the renal function test results between the two groups (samples with and without adding gold nanoparticle solution) was performed. The results of this investigation are shown in [Table 1]. There was a significant difference observed between the two groups. This finding shows that the gold nanoparticle solution is an important interference to the clinical chemistry analytical system. The interpretation of renal function in cases receiving nanoparticle such as those who are receiving novel nanotherapy has to be made with caution on the possible laboratory interference.
Table 1: Results of renal function tests in the two study groups.

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Conflict of interest:

None declared.

   References Top

Sereemaspun A, Rojanathanes R, Wiwanitkit V. Effect of gold nanoparticle on renal cell: An implication for exposure risk. Ren Fail 2008;30:323-5.  Back to cited text no. 1
Doudi M, Setorki M. The effect of gold nanoparticle on renal function in rats. Nanomed J 2014;1:171-9.  Back to cited text no. 2
Noori A, Karimi F, Fatahian S, Yazdani F. Effects of zinc oxide nanoparticles on renal function in mice. Int J Biosci 2014;5:140-6.  Back to cited text no. 3

Correspondence Address:
Sora Yasri
KMT Primary Care Center, Bangkok
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DOI: 10.4103/1319-2442.252926

PMID: 30804296

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