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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2019  |  Volume : 30  |  Issue : 3  |  Page : 701-705
Does severe ADAMTS13 deficiency in thrombotic microangiopathy rule out complement-mediated atypical hemolytic uremic syndrome

Department of Pediatrics, Division of Pediatric Nephrology, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Venkatesh Arumugam
Department of Pediatrics, Division of Pediatric Nephrology, Pediatrics Unit II, Christian Medical College, Vellore, Tamil Nadu
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DOI: 10.4103/1319-2442.261349

PMID: 31249236

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In evaluating a patient with thrombotic microangiopathy (TMA), it is necessary to rule out thrombotic thrombocytopenic purpura before a diagnosis of atypical hemolytic uremic syndrome (aHUS) is made. There have been reports that mutations of complement factors can coexist with partial A Disintegrin and Metalloproteinase with a ThromboSpondin type 1 motif, member 13 deficiency. Here, we report the case of a 6-year-old girl who was initially diagnosed as nephrotic syndrome and developed TMA after five years of onset of illness. She had poor response to treatment and had multiple relapses due to associated complement factor mutation. Hence, genetic evaluation has to be considered in all children presenting with aHUS.

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