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| Year : 2020 | Volume
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| Issue : 2 | Page : 562 |
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| Author's reply |
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Mukta Mantan
Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, University of Delhi, New Delhi, India
Click here for correspondence address and email
| Date of Web Publication | 09-May-2020 |
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How to cite this article:
Mantan M. Author's reply. Saudi J Kidney Dis Transpl 2020;31:562 |
To the Editor,
We thank Mr. Akbar Ali, Dr. Raheel Allana and Mr. Rahim Jandani for their comments on our article entitled “Infection associated Relapses in Children with Nephrotic Syndrome:
A Short-term Outcome Study.”[1] We agree with their comments that OR should be interpreted with caution when the 95% confidence interval (CI) tends to include 1. This usually occurs when the sample size is small.[2]As the sample size calculation was for all infections combined and not for individual infections in our study this variation occurred.
The odds of attaining remission with pneumonia, spontaneous bacterial peritonitis, and diarrhea were much higher than those with acute respiratory tract infections despite the 95% CI being wide. As larger proportion of children with bacterial infections attained spontaneous remission in the study compared to upper respiratory tract infections the odds ratios appeared to have a clinical significance though not statistically significant.
In single-center studies with small sample size of uncommon conditions these observations often provide suggestions for future studies on the topic with larger sample size and possibly multicentric study design. Hence, we too conclude that while the odds ratios were not statistically significant the clinical significance of attainment of remission after bacterial infections needs further evaluation in larger studies.
 References | |  |
| 1. | Manta M, Singh S. Infection associated relapses in children with nephrotic syndrome: A short-term outcome study. Saudi J Kidney Dis Transpl 2019;30:1245-53.  [ PUBMED] [Full text] |
| 2. | Hazra A. Using the confidence interval confidently. J Thorac Dis 2017;9:4125-30. |
Correspondence Address:
Mukta Mantan
Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, University of Delhi, New Delhi
India
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DOI: 10.4103/1319-2442.284040 PMID: 32394938 
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