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| Year : 2020 | Volume
: 31
| Issue : 2 | Page : 568-569 |
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| Risk for renal carcinogenesis due to exposure to ochratoxin A contaminated roasted coffee: An assessment from Thailand |
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Beuy Joob1, Viroj Wiwanitkit2
1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Dr. D. Y. Patil University, Pune, Maharashtra, India
Click here for correspondence address and email
| Date of Submission | 22-Jan-2019 |
| Date of Acceptance | 23-Jan-2019 |
| Date of Web Publication | 09-May-2020 |
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How to cite this article:
Joob B, Wiwanitkit V. Risk for renal carcinogenesis due to exposure to ochratoxin A contaminated roasted coffee: An assessment from Thailand. Saudi J Kidney Dis Transpl 2020;31:568-9 |
How to cite this URL:
Joob B, Wiwanitkit V. Risk for renal carcinogenesis due to exposure to ochratoxin A contaminated roasted coffee: An assessment from Thailand. Saudi J Kidney Dis Transpl [serial online] 2020 [cited 2021 Jun 21];31:568-9. Available from: https://www.sjkdt.org/text.asp?2020/31/2/568/284043 |
To the Editor,
Ochratoxin A (OTA) is an important myco- toxin.[1] It is an important problematic contaminant in several foods. The contamination in coffee is also reported.[2] Ochratoxin can cause nephrotoxicity.[1] The relationship with renal carcinogenesis is also reported.[3] The risk of renal carcinogenesis due to exposure to OTA becomes an important consideration in public health at present. The recent report from the USA showed the negligible risk of renal carcinogenesis due to exposure to OTA contaminated in food.[4] In the present report, the authors use the standard risk assessment technique to assess the risk for renal carcino- genesis due to exposure to OTA contaminated roasted coffee based on the data on contamination in Thailand. The standard referencing protocols for risk assessment published by Mitchell et al[4] were used in the present study. The setting in the present study is Thailand, a tropical country in Indochina. The primary data for further assessment are the data on OTA in roasted coffee in Thailand. According to the recent local study (available online at http://www.lib.kku.ac.th/KUCONF/KC440605 8.pdf), 6.25% of locally roasted coffee samples collected from supermarkets in Bangkok, capital of Thailand, are contaminated with OTA and the average contaminated level is equal 3.2 ppb. Based on the assumption from the previous report[4] that 60% of adults are coffee drinkers, the mean OTA level is equal to 0.051 ng/kg body weight/day. Then the margin of safety (MOS), by comparing it to threshold nongenotoxic carcinogen (4 ng/kg body weight/day, National Cancer Research Institute, Canada); if the MOS >1, it is considered that there is a risk,[4] is calculated. According to the present study, the MOS is 0. 013.Based on the present assessment, it can show that there is no risk for renal carcinogenesis due to exposure to OTA contaminated roasted coffee in our setting, Thailand.
Conflict of interest: None declared.
 References | |  |
| 1. | Malir F, Ostry V, Pfohl-Leszkowicz A, Malir J, Toman J. Ochratoxin A: 50 years of research. Toxins (Basel) 2016;8. pii: E191.  |
| 2. | Taniwaki MH. An update on ochratoxigenic fungi and ochratoxin A in coffee. Adv Exp Med Biol 2006;571:189-202. |
| 3. | Marin-Kuan M, Cavin C, Delatour T, Schilter B. Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms. Toxicon 2008;52:195-202. |
| 4. | Mitchell NJ, Chen C, Palumbo JD, Bianchini A, Cappozzo J, Stratton J, et al. A risk assessment of dietary Ochratoxin a in the United States. Food Chem Toxicol 2017;100:265-73. |
Correspondence Address:
Beuy Joob
Sanitation 1 Medical Academic Center, Bangkok
Thailand
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DOI: 10.4103/1319-2442.284043 PMID: 32394941 
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