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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2020  |  Volume : 31  |  Issue : 6  |  Page : 1361-1365
Effect of branched chain amino acid supplementation on dialysis adequacy and nutritional parameters in hemodialysis patients


1 Department of Nephrology, Theodor Bilharz Research Institute, Giza, Egypt
2 Department of Internal Medicine, Cairo University, Cairo, Egypt
3 Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt

Correspondence Address:
Sameh Abou Zeid
Department of Nephrology, Theodor Bilharz Research Institute Giza
Egypt
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DOI: 10.4103/1319-2442.308346

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Malnutrition in hemodialysis (HD) patients is caused by deficient nutrient and protein intake and has a negative impact on patient outcomes. The assessment of dialysis adequacy in these patients depends to a large extent on the calculation of urea clearance using dialyzer clearance of urea (K) multiplied by the duration of the dialysis treatment (t, in minutes) divided by the volume of distribution of urea in the body (V, in mL); Kt/V. This study aims to detect the effect of branched-chain amino acid (BCAA) supplementation on Kt/V and other nutritional parameters such as serum albumin as well as body mass index. Forty-six patients from the HD Unit of Mostafa Mahmoud Hospital were included in this study. Daily intake of BCAA was continued for three months. At the start of the study, before the intervention, and at the end of the 3rd month, we measured serum albumin, valine, leucine, iso-leucine, and Kt/V. Analysis of data was performed using paired and independent t-test. We found that BCAA has a highly significant effect on increasing the level of albumin, leucine, isoleucine, valine, and Kt/V in HD patients (P <0.001) (Paired t-test). BCAA supplements could be used in this patient population to improve dialysis adequacy and outcome.


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