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| CASE REPORT |
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| Year : 2020 |
Volume
: 31 | Issue : 6 | Page
: 1415-1419 |
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The significance of anti-phospholipase receptor antibodies in a patient with membranous nephropathy
Jayaprakash R Dasari1, Pallavi Reddy2, Yeshwanter Radhakrishnan2, Nikhil Nair3, Ronith Chakraborty4, Lena Nemer5, Rupesh Raina6
1 Department of Nephrology, Americare Kidney Institute, Akron, USA
2 Department of Internal Medicine, Akron General Medical Center, Akron, USA
3 Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA
4 Department of Chemistry, Eastern Michigan University Ypsilanti, Michigan, USA
5 Department of Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA
6 Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General; Department of Nephrology, Akron Children’s Hospital, Akron, Ohio, USA
Correspondence Address:
Nikhil Nair
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio
USA
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DOI: 10.4103/1319-2442.308360 
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Membranous nephropathy (MN) is the major cause of nephrotic syndrome in adults and may be secondary to systemic lupus erythematosus or malignancy in 25% of patients. Without any etiology, it is called primary MN, which is usually associated with phospholipase A2 (PLA2) receptor antibodies. Secondary MN can appear months before a secondary cause is identified. Here, we report a case of MN, that was found to be secondary to pancreatic adenocarcinoma and positive for PLA2 receptor antibodies.
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