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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2020  |  Volume : 31  |  Issue : 6  |  Page : 1415-1419
The significance of anti-phospholipase receptor antibodies in a patient with membranous nephropathy

1 Department of Nephrology, Americare Kidney Institute, Akron, USA
2 Department of Internal Medicine, Akron General Medical Center, Akron, USA
3 Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA
4 Department of Chemistry, Eastern Michigan University Ypsilanti, Michigan, USA
5 Department of Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA
6 Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General; Department of Nephrology, Akron Children’s Hospital, Akron, Ohio, USA

Correspondence Address:
Nikhil Nair
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio
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DOI: 10.4103/1319-2442.308360

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Membranous nephropathy (MN) is the major cause of nephrotic syndrome in adults and may be secondary to systemic lupus erythematosus or malignancy in 25% of patients. Without any etiology, it is called primary MN, which is usually associated with phospholipase A2 (PLA2) receptor antibodies. Secondary MN can appear months before a secondary cause is identified. Here, we report a case of MN, that was found to be secondary to pancreatic adenocarcinoma and positive for PLA2 receptor antibodies.

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