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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2021  |  Volume : 32  |  Issue : 2  |  Page : 554-558
Acute tubulointerstitial nephritis in two sisters with simultaneous uveitis in one

Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Ali Derakhshan
Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-2442.335470

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Tubulointerstitial nephritis uveitis syndrome (TINU) is an underdiagnosed entity, defined by association of uveitis and TIN with no evidence of concomitant systemic disease that might present with both ocular and renal manifestations. Although not common, it needs awareness and collaborations of pediatricians and ophthalmologists for prompt diagnosis and treatment. The exact pathogenesis of the disease is poorly understood, and it predominantly affects female adolescents. Since its early description at 1975, many cases have been reported but only a few were familial case reports. Herein, we report TIN in two sisters, first one with uveitis (TINU) and second one, eight years later at the same age without uveitis.

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