Saudi Journal of Kidney Diseases and Transplantation

: 1996  |  Volume : 7  |  Issue : 1  |  Page : 40--41

Authors' reply

T Timothy Paul, KS Ramprasad, Faissal A.M Shaheen 
 Saudi Center for Organ Transplantation, P.O. Box 27049, Riyadh 11417, Saudi Arabia

Correspondence Address:
T Timothy Paul
Saudi Center for Organ Transplantation, P.O. Box 27049, Riyadh 11417
Saudi Arabia

How to cite this article:
Paul T T, Ramprasad K S, Shaheen FA. Authors' reply.Saudi J Kidney Dis Transpl 1996;7:40-41

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Paul T T, Ramprasad K S, Shaheen FA. Authors' reply. Saudi J Kidney Dis Transpl [serial online] 1996 [cited 2020 Oct 23 ];7:40-41
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Full Text

We thank Subramanian for his comments. Several tests are available to identify non­responders to erythropoietin therapy. Erythropoietic response to therapy in the form of reticulocyte count is one of them. However, this test is impresice due to its binominal counting statistics and inter­observor variabilities regarding identification of a reticulocyte [1] . A new parameter using fluorecent activated cytometric analysis of reticulocytes by thiazol orange, namely the reticulocyte maturation index (RMI), is a rapid, simple and precise method of counting reticulocytes. The RMI thus, offers an independent parameter of erythro­poietic activity. However, the accuracy of this method may become less owing to be presence to Howell-Jolly bodies, nucleated red blood cells, sickled cells or giant platelets [1] .

Another test, namely assay of plasma concentration of erythropoietin, has also been suggested recently as an useful adjunct to the investigation of poor response to erythropoietin [2] .


1Pappas AA, Owens RB, Flick JI. Reticulocyte counting by flow cytometry. A comparison with manual methods. Ann Clin Lab Sci 1992;22(2):125-32.
2Strachan J, Fleming L, Dick J, et al. Poor responses to eruthropoietin. BMJ 1995;311:633.