LETTER TO THE EDITOR
Year : 1996 | Volume
: 7 | Issue : 1 | Page : 40--41
T Timothy Paul, KS Ramprasad, Faissal A.M Shaheen
Saudi Center for Organ Transplantation, P.O. Box 27049, Riyadh 11417, Saudi Arabia
T Timothy Paul
Saudi Center for Organ Transplantation, P.O. Box 27049, Riyadh 11417
|How to cite this article:|
Paul T T, Ramprasad K S, Shaheen FA. Authors' reply.Saudi J Kidney Dis Transpl 1996;7:40-41
|How to cite this URL:|
Paul T T, Ramprasad K S, Shaheen FA. Authors' reply. Saudi J Kidney Dis Transpl [serial online] 1996 [cited 2020 Oct 23 ];7:40-41
Available from: https://www.sjkdt.org/text.asp?1996/7/1/40/39542
We thank Subramanian for his comments. Several tests are available to identify nonresponders to erythropoietin therapy. Erythropoietic response to therapy in the form of reticulocyte count is one of them. However, this test is impresice due to its binominal counting statistics and interobservor variabilities regarding identification of a reticulocyte  . A new parameter using fluorecent activated cytometric analysis of reticulocytes by thiazol orange, namely the reticulocyte maturation index (RMI), is a rapid, simple and precise method of counting reticulocytes. The RMI thus, offers an independent parameter of erythropoietic activity. However, the accuracy of this method may become less owing to be presence to Howell-Jolly bodies, nucleated red blood cells, sickled cells or giant platelets  .
Another test, namely assay of plasma concentration of erythropoietin, has also been suggested recently as an useful adjunct to the investigation of poor response to erythropoietin  .
|1||Pappas AA, Owens RB, Flick JI. Reticulocyte counting by flow cytometry. A comparison with manual methods. Ann Clin Lab Sci 1992;22(2):125-32.|
|2||Strachan J, Fleming L, Dick J, et al. Poor responses to eruthropoietin. BMJ 1995;311:633.|