Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2004  |  Volume : 15  |  Issue : 1  |  Page : 27--33

Post Renal Transplantation Tubulopathies in Children: A 9-Year Experience at a Tertiary Care Centre


Alia Al-Ibrahim1, Sami Sanjed2, Abbas Al-Abbad1, Essam Al-Sabban2, Khalid Al-Shaibani1 
1 Department of Pediatrics King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
2 Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon

Correspondence Address:
Alia Al-Ibrahim
Pediatric Nephrology, Sulaimania Children«SQ»s Hospital, P.O. Box 59046, Riyadh 11525
Saudi Arabia

To evaluate the incidence of tubulopathies in the long-term follow-up of children post renal transplantation, we reviewed the records of 43 patients from 1987-1996. There were 24 (56%) boys. The age of patients at the time of transplant ranged from 2.7 to 15 years. Eighteen children (78%) had transplantation from cadaver donors (CAD). Thirty-two (74%) patients were transplanted in Saudi Arabia and 11(26%) were transplanted abroad. Significant tubular dysfunction developed in 72% of patients. Renal Tubular Acidosis (RTA) occurred in 23/43 (53%) patients. The patients who received CAD grafts required higher mean dose of bicarbonate and longer duration of therapy compared to living related donors (LRD) recipients ( mean dose of 1.7 Vs 0.5 meq/kg/day and mean duration of 18 Vs 3 ½ months, respectively). Hypophosphatemia of various degrees of severity (0.4-0.8 mmol/1) was detected in 12 (28%) patients. Those who received CAD grafts required higher mean dose of phosphate and longer period of therapy than those who received LRD grafts. Hypomagnesemia requiring supplemental magnesium therapy occurred in 4 (9%) patients, all received tacrolimus therapy. In four patients with hypomagnesemia, this was mild and transient. Hypokalemia was found in 5 (11.5%) patients; all had CAD grafts. We conclude that tubulopathies were a frequent complication post renal transplantation in our population. They were more severe in the patients who received CAD grafts. However, the defects were controllable and transient.


How to cite this article:
Al-Ibrahim A, Sanjed S, Al-Abbad A, Al-Sabban E, Al-Shaibani K. Post Renal Transplantation Tubulopathies in Children: A 9-Year Experience at a Tertiary Care Centre.Saudi J Kidney Dis Transpl 2004;15:27-33


How to cite this URL:
Al-Ibrahim A, Sanjed S, Al-Abbad A, Al-Sabban E, Al-Shaibani K. Post Renal Transplantation Tubulopathies in Children: A 9-Year Experience at a Tertiary Care Centre. Saudi J Kidney Dis Transpl [serial online] 2004 [cited 2021 Mar 6 ];15:27-33
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2004;volume=15;issue=1;spage=27;epage=33;aulast=Al-Ibrahim;type=0