Saudi Journal of Kidney Diseases and Transplantation

RENAL DATA FROM THE ARAB WORLD
Year
: 2004  |  Volume : 15  |  Issue : 4  |  Page : 503--507

Renal Biopsy Findings in the Kingdom of Bahrain: A 13-Year Retrospective Study


Ahmed Al Arrayed1, Sara M George2, AK Malik2, Sameer Al Arrayed1, S Rajagopalan1, Aziz Al Arrayed1, Salah Eldin Sharqawi1, KS Ratnakar2, Eman Fareed2, Fadhel Al Sabag2,  
1 Department of Nephrology, Salmaniya Medical Complex, Manama, Bahrain
2 Department of Pathology, Salmaniya Medical Complex, Manama, Bahrain

Correspondence Address:
Ahmed Al Arrayed
Department of Nephrology, Salmaniya Medical Complex, P.O. Box 12, Manama
Bahrain

Abstract

Glomerular diseases continue to be the leading cause of end-stage renal disease globally. Hence, it is important to recognize the pattern of these diseases in any given geographical area. A total of 498 renal biopsies performed on patients with proteinuria, hematuria and mild to moderate renal impairment during a period of 13 years (between January 1990 and December 2002) at the Salmaniya Medical Complex (a tertiary care hospital of the Kingdom of Bahrain), were reviewed and categorized. Primary glomerular disease accounted for two-third of the glomerular diseases, which in turn constituted 44.8% of all renal biopsies. The most common histological lesion was minimal change disease (30%). Focal and segmental glomerulosclerosis was the second most common lesion (23.8%) followed by membranoproliferative glomerulonephritis (14.3%). Secondary glomerular disease comprised 33.6% of glomerular diseases (22.7% of all the renal biopsies) with lupus nephritis forming the commonest lesion (38.9%) followed by diabetic nephropathy (31.9%) and hypertension (20.4%). Tubulointerstitial diseases accounted for 13.1% of all renal biopsies whereas transplant diseases were noted in 12.2%. The miscellaneous group including inadequate biopsies constituted 7.2% of all the biopsies. The results of this analysis were compared with surveys from other parts of the World.



How to cite this article:
Al Arrayed A, George SM, Malik A K, Al Arrayed S, Rajagopalan S, Al Arrayed A, Sharqawi SE, Ratnakar K S, Fareed E, Al Sabag F. Renal Biopsy Findings in the Kingdom of Bahrain: A 13-Year Retrospective Study.Saudi J Kidney Dis Transpl 2004;15:503-507


How to cite this URL:
Al Arrayed A, George SM, Malik A K, Al Arrayed S, Rajagopalan S, Al Arrayed A, Sharqawi SE, Ratnakar K S, Fareed E, Al Sabag F. Renal Biopsy Findings in the Kingdom of Bahrain: A 13-Year Retrospective Study. Saudi J Kidney Dis Transpl [serial online] 2004 [cited 2021 Jan 26 ];15:503-507
Available from: https://www.sjkdt.org/text.asp?2004/15/4/503/32885


Full Text

 Introduction



Glomerular disease represents the most common cause of end-stage renal disease in many countries. Its pattern, however, differs in different countries. The glomeruli are affected by a variety of environmental insults and systemic disorders apart from the primary glomerulopathies. Glomerular diseases generally present with variable degrees of proteinuria, hematuria, hypertension and/or impaired renal function. Some glomerular diseases may be indolent and develop into insidious uremia.

Renal biopsy plays a fundamental role in the evaluation of proteinuric patients not only to establish an accurate diagnosis but also to help deciding on appropriate treatment and assess the prognosis.

There are no data on the pattern of glomerular disease in the Kingdom of Bahrain. A retro­spective study was therefore undertaken, to analyze the glomerular diseases by reviewing the renal biopsies performed during a 13­year period (January 1990 to December 2002) at the Salmaniya Medical Complex.

 Materials and Methods



The patients referred to the Nephrology Department at the Salmaniya Medical Com­plex, Kingdom of Bahrain and who were subjected to kidney biopsy, from January 1990 to December 2002, constituted the subjects of this study. A total of 498 renal biopsies were performed in this period and were reviewed retrospectively to analyze the pattern of glome­rular diseases.

There were 288 males and 210 females with age ranging from two days to 80 years. The demographics of Bahrain reveal a cosmopolitan population with nationals of many foreign countries, particularly from South Asia, con­stituting the bulk of the expatriate work force.

The patients' ethnic origin was classified into two categories for the purpose of this study: Arabs and non-Arabs, the majority of whom being Indians and Pakistanis.

The indications for renal biopsy included proteinuria, unexplained microscopic or macro­scopic hematuria, systemic disease with evi­dence of renal involvement, unexplained renal impairment and renal impairment in post­transplant patients.

All samples were obtained by percutaneous method using a trucut needle under ultrasound guidance. Three renal biopsy samples were taken from each patient, which were processed for light microscopy, immunofluorescence and electron microscopic studies. Sections were made from formalin fixed paraffin embedded tissue and stained by hematoxylin-eosin, periodic-acid schiff (PAS) and Jones stains for light microscopy; all samples were examined by a histopathologist.

Immunofluorescence microscopy panel included staining for IgA, IgM, IgG, C3, C 1q and fibrinogen. Electron microscopic study was performed at laboratories in France or the United Kingdom.

The patients' data were obtained from the medical records.

 Results



A total of 498 renal biopsies were analyzed. Glomerular disease constituted 67.5% of the total renal biopsies. Of the patients with glome­rular diseases, 75% were Arabs and the male to female ratio was 1.4:1. The histopathologic profile of the renal biopsies and the sex and ethnic distribution of the patients are given in [Table 1].

Primary glomerular disease constituted 66.4% of the glomerular diseases while secondary glo­merular disease accounted for 33.6% [Table 2].

Among primary glomerular diseases, minimal change disease (MCD) was the commonest lesion (30%). The second commonest diagnosis was focal and segmental glomerulosclerosis (FSGS, 23.8%). The other types of primary glomerular disease, their numbers and the age, sex and ethnic distribution of the patients are given in [Table 3].

Lupus nephritis (38.9%) was the commonest cause of secondary glomerular disease followed by diabetic nephropathy (31.9%) and hyper­tensive nephropathy (20.4%). [Table 4] shows the histopathologic profile along with the age, sex and ethnic distribution of the secondary glomerular diseases.

There were more males than females affected with primary glomerular diseases in general (58.3% vs. 41.7%). When assessed indivi­dually, the male preponderance was evident in FSGS (62.3% vs. 37.7%), MCD (67.2% vs. 32.8%) and membranous glomeruloneph­ritis (63.3% vs. 36.7%). The age of patients with primary glomerular diseases ranged from five weeks to 75 years.

Females were more frequently affected with secondary glomerular disease than males (51.3% vs. 48.7%). This was particularly evident with lupus nephritis (75% vs. 25%) and Henoch Schonlein Purpura (two cases, both were female). However, hypertensive and diabetic nephropathy were more common in males. The age of patients with secondary glomerular diseases ranged from 10 to 80 years.

 Discussion



In the literature, there is limited population­based epidemiological data on the spectrum of biopsy proven glomerular diseases. A review of renal biopsy data can give some insight into the spectrum of clinically significant renal disease in the community. Our institution receives renal biopsies from the entire island nation of Bahrain with a population of 656,397, which includes 228,424 non­nationals.

This report is a national epidemiological study of the biopsy-proven renal diseases. The rate for biopsy-proven renal diseases underestimates the true prevalence of diseases, as not all patients with renal disease are biopsied.

Bahrain has an expatriate population which constitutes nearly one-third of the total popu­lation. However, expatriates constituted only a quarter of the biopsies reviewed in this report.

The incidence rates of renal biopsies per­formed, vary in different countries. We have an incidence of 5.8/100000/year, which was similar to the studies in Spain [1] and Mace­donia, [2] while the report from Australia [3] showed a much higher incidence of 21/100000/year. An epidemiological study from the United Arab Emirates [4] (UAE) had 490 biopsies over an 18-year period, which is less than in our series. These variations could be because of the time span of the reviews and/or because of the different biopsy polices adopted by different centers.

Glomerular diseases in our study constituted 3.9/100000/year, which is 67% of the total renal biopsies. This is similar to reports from Australia, Denmark, Iran and Senegal, [3],[5],[6],[7] while data from the UAE and Saudi Arabia [4],[8] revealed a higher rate of glomerular diseases.

This discrepancy may be due to the fact that Saudi Arabia and UAE reported on only native kidney biopsies while our study also included transplant biopsies.

The 44.8% prevalence of primary glomerular diseases among the total renal biopsies in our series is low, compared to studies from UAE, Iran, Senegal and Saudi Arabia. [4],[6],[7],[8] This could be explained by the high rate of inadequate biopsy samples (approximately 10%) as well as inclusion of transplant biopsies in our study.

Amongst the primary glomerular diseases, the various conditions differ in their incidences in different studies. Our study showed a high incidence of MCD and FSGS, while a study from Saudi Arabia [8] reported a high incidence of FSGS and in the UAE [4] a high incidence of membranoproliferative glomerulonephritis was reported. This difference could be due to a selection bias in the study from Saudi Arabia which is a single hospital study; however, the reason for the major difference between the report from UAE and our study needs to be explored. Changing incidences of glomerular diseases over a time frame have been found in different communities. [9] This could be because of genetic and environmental factors.

Vasculitis was not a major cause in any of the studies from the Arab Countries including our study. However, it formed a major diag­nosis in the Australian and Spanish studies. [1],[3]

Amongst the secondary glomerular diseases, lupus nephritis constituted the commonest condition with female preponderance, which was consistent with the reports from Spain, Australia and some Arab countries. [1],[3],[4],[6],[7],[8]

 Conclusion



There exists a wide variability in the diffe­rent categories of primary and secondary glomerular diseases in different parts of the world and even within the Arabian Gulf countries. Future studies should be directed to analyze the causes for these variations.

References

1Rivera F, Lopez-Gomez JM, Perez-Garcia R. Frequency of renal pathology in Spain 1994-1999. Nephrol Dial Transplant 2002; 17:1594-602.
2Polenakovic MH, Grcevska L, Dzikova S. The incidence of biopsy-proven primary glomerulonephritis in the Republic of Macedonia - long term follow-up. Nephrol Dial Transplant 2003;18(Suppl 5):v26-27.
3Briganti EM, Dowling J, Finlay M, et al. The incidence of biopsy-proven glomerulo­nephritis in Australia. Nephrol Dial Transplant 2001;16:1364-7.
4Yahya TM, Pingle A, Boobes Y, Pingle S. Analysis of 490 Kidney biopsies: data from the United Arab Emirates Renal Diseases Registry. J Nephrol 1998;11(3):148-50.
5Heaf J, Lokkegaard H, Larsen S. The epidemiology and prognosis of glomerulo­nephritis in Denmark 1985-1997. Nephrol Dial Transplant 1999;14:1889-97.
6Antonoovych TT, Sabnis SG, Broumand BB. A study of membranoproliferateive glomerulo­nephritis in Iran. Ann Saudi Med 1999; 19(6):505-10.
7Abdou N, Boucar D, Fary KA, et al. Histopathological Profiles of Nephropathies in Senegal. Saudi J Kidney Dis Transplant 2003;14(2):212-4.
8Mitwalli AH, Wakeel JS, Al Mohaya SS, et al. Pattern of Glomerular Disease in Saudi Arabia. Am J Kidney Dis 1996;27(6):797-802.
9Braden GL, Mulhem JG, O'Shea MH, Nash SR, Ucci AA Jr, Germain MJ. Changing incidence of glomerular diseases in adults. Am J Kidney Dis 2000;35(5);878-83.