Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2006  |  Volume : 17  |  Issue : 2  |  Page : 171--176

Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis Patients


Abdulkareem Alsuwaida 
 Department of Nephrology, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Abdulkareem Alsuwaida
Department of Nephrology, King Saud University, P.O. Box 2925, Riyadh 11461
Saudi Arabia

Brain natriuretic peptide (BNP) levels increase in patients with congestive heart failure. Theoretically, BNP levels can be helpful in the determination of the DQdry weightDQ of hemodialysis patients. To evaluate the effect of hemodialysis on the plasma concentration of BNP and to determine the factors that affect BNP levels during hemodialysis in patients with chronic renal failure, we studied five stable patients with chronic renal failure. A total of 15 blood samples were obtained for BNP levels at 24, 48 and 72 hours after the last hemodialysis session. The plasma BNP levels did not change significantly either with ultrafiltration volume or with time since last dialysis. However, the BNP levels correlated positively with the erythropoietin (EPO) dose (r=0.98, P<0.001) and negatively with the serum albumin levels (r = 0.94, P=0.02). Univariate analysis showed that the EPO dose (P=0.001) and the albumin level (P=0.02) were significant predictors of BNP level. Adjusted multivariate analysis showed significant interaction between the EPO dose and the albumin level (P=0.01, P=0.03 respectively. In conclusion: the plasma BNP levels were not significantly influenced by ultrafiltration volume or time since last dialysis. However, the BNP levels may be a useful prognostic parameter for assessing the risk of cardiovascular morbidity and mortality in hemodialysis patients.


How to cite this article:
Alsuwaida A. Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis Patients.Saudi J Kidney Dis Transpl 2006;17:171-176


How to cite this URL:
Alsuwaida A. Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis Patients. Saudi J Kidney Dis Transpl [serial online] 2006 [cited 2021 Mar 5 ];17:171-176
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2006;volume=17;issue=2;spage=171;epage=176;aulast=Alsuwaida;type=0