LETTER TO EDITOR
Year : 2007 | Volume
: 18 | Issue : 2 | Page : 262-
Up-Date on Renal Fibrosis: A Time for Action
E Nigel Wardle
London NW1 8JS, United Kingdom
Correspondence Address:
E Nigel Wardle
London NW1 8JS
United Kingdom
How to cite this article:
Wardle E N. Up-Date on Renal Fibrosis: A Time for Action.Saudi J Kidney Dis Transpl 2007;18:262-262
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How to cite this URL:
Wardle E N. Up-Date on Renal Fibrosis: A Time for Action. Saudi J Kidney Dis Transpl [serial online] 2007 [cited 2022 Jul 3 ];18:262-262
Available from: https://www.sjkdt.org/text.asp?2007/18/2/262/32322 |
Full Text
To the Editor:
Readers of my original article [1] may have concluded that on the subject of Fibrosis there is a vast amount of theoretical information, [2] but for the working nephrologists there is only the knowledge that treating patients with a combination of ACE inhibitors and ARBs could lessen fibrosis, or alternatively there is the Et-1 antagonist bosentan, which is not entirely free of side-effects.
However there is encouraging news. It is reported that mycophenolate inhibits mesangial cell proliferation and reduces the synthesis of extracellular matrix. [3] Then low dose rapamycin has been found to act similarly, albeit by a different mechanism. [4] Finally when type II diabetics are taking glibenclamide this agent stops extracellular matrix formation by mesangial cells exposed to a high glucose. [5]
References
| 1 | Wardle E N. Renal Fibrosis, Origin and possible Interventions:A Time for Action. Saudi J Kidney Dis Transpl 2006;17{2}:137-48. |
| 2 | Teng Y, Zeisberg M, Kalluri R. Transcriptional regulation of epithelialmesenchymal transition. J Clin Invest 2007;117:304-6. |
| 3 | Ha H, Kim M S, Park J, et al. Mycophenolic acid inhibits mesangial cell activation through p38 MAPkinase inhibition. Life Science 2006;79:1561-7 |
| 4 | Lock H R, Sacks S H, Robson M G. Rapamycin at sub-immunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production. Am J Physiol Renal Physiol 2007;292:F76-F81. |
| 5 | Giannico G, Cortes P, Baccora MH, et al. Glibenclamide prevents increased extracellular matrix formation induced by a high glucose concentration in mesangial cells. Am J Physiol physiol Renal 2007;292:F57-F65. |
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