Saudi Journal of Kidney Diseases and Transplantation

RENAL DATA FROM THE ARAB WORLD
Year
: 2008  |  Volume : 19  |  Issue : 6  |  Page : 1001--1008

Clinical and immunological manifestations of systemic lupus erythematosus: A study on 146 south Tunisian patients


Moez Jallouli1, Makram Frigui1, Mohamed Ben Hmida2, Sameh Marzouk1, Neila Kaddour1, Zouheir Bahloul1 
1 Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia
2 Department of Nephrology, Hedi Chaker University Hospital, Sfax, Tunisia

Correspondence Address:
Moez Jallouli
Department of Internal Medicine, Hedi Chaker University Hospital, Sfax
Tunisia

The objective of this study was to determine the main clinical and laboratory features as well as the morbidity and mortality of systemic lupus erythematosus (SLE) in a population of patients predominantly from the south of Tunisia. A retrospective review of a well documented population of 146 patients with SLE was undertaken. All patients fulfilled four or more criteria defined by the American College of Rheumatology. The mean age at presentation was 29.2 years (range 6-55) and the mean duration of follow-up was 62 months (range 0.25-374). Musculoskeletal (84.2%) and mucocutaneous (75.3%) were the most frequent clinical mani­festations. Antinuclear antibodies were detected in 97.3%, anti-DNA antibodies in 69.2% and anti-Sm in 39.2% of the patients. Anti-cardiolipin antibodies and lupus anticoagulant were ob­served respectively in 71.6% and 37.8% of the patients. The five-year survival rate in our series was 92%. Renal involvement and thrombocytopenia were associated with poor prognosis (p< 0.05). The clinical and immunological characteristics of our SLE patients are largely comparable to most major studies. Main differences included prominent major organ damage and high pre­valence of anti-Sm and anti-cardiolipin antibodies.


How to cite this article:
Jallouli M, Frigui M, Hmida MB, Marzouk S, Kaddour N, Bahloul Z. Clinical and immunological manifestations of systemic lupus erythematosus: A study on 146 south Tunisian patients.Saudi J Kidney Dis Transpl 2008;19:1001-1008


How to cite this URL:
Jallouli M, Frigui M, Hmida MB, Marzouk S, Kaddour N, Bahloul Z. Clinical and immunological manifestations of systemic lupus erythematosus: A study on 146 south Tunisian patients. Saudi J Kidney Dis Transpl [serial online] 2008 [cited 2021 Jan 20 ];19:1001-1008
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2008;volume=19;issue=6;spage=1001;epage=1008;aulast=Jallouli;type=0