Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2008  |  Volume : 19  |  Issue : 6  |  Page : 911--917

Correlation of urinary monocyte chemo-attractant protein-1 with other parameters of renal injury in type-II diabetes mellitus


Salwa Ibrahim1, Laila Rashed2 
1 Department of Internal Medicine, Cairo University, Egypt
2 Department of Medical Biochemistry, Cairo University, Egypt

Correspondence Address:
Salwa Ibrahim
Department of Internal Medicine, Cairo University
Egypt

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in the western world. Increased number of interstitial macrophages has been observed in biopsies from patients with DN. Monocyte chemo-attractant protein-1 (MCP-1) is the strongest known chemo­tactic factor for monocytes and is upregulated in DN. We examined urinary levels of MCP-1 in patients with type-2 diabetes mellitus (DM) to assess its possible correlation with other para­meters of renal injury. The urinary MCP-1 level was assessed in 75 patients with type-2 DM (25 patients each with no microalbuminuria, with macroalbuminuria and, with renal impairment) and compared them with matched healthy control subjects. The HbA1c and estimated glomerular fil­tration rate (eGFR) derived from the abbreviated Modification of Diet in Renal Disease (MDRD) equation were examined in the study groups in relation to the urinary MCP-1. The urinary MCP-1 level was significantly higher in patients with micro and macroalbuminuria (167.41 ± 50.23 and 630.87 ± 318.10 ng/gm creatinine respectively) as compared with normoalbuminuric patients and healthy controls (63.85 ± 21.15 and 61.50 ± 24.81 ng/gm creatinine, p< 0.001). MCP-1 correlated positively with urine albumin/creatinine ratio (ACR) (r= 0.75, p< 0.001), HbA1c (r= 0.55, p< 0.001) and inversely with eGFR (r=-0.60, p< 0.001). Our findings suggest that hyperglycemia is associated with increased urinary levels of MCP-1 that is closely linked to renal damage as reflected by proteinuria and eGFR levels. Collectively, these findings suggest that MCP-1 is in­volved in the pathogenesis of diabetic nephropathy through its various stages.


How to cite this article:
Ibrahim S, Rashed L. Correlation of urinary monocyte chemo-attractant protein-1 with other parameters of renal injury in type-II diabetes mellitus.Saudi J Kidney Dis Transpl 2008;19:911-917


How to cite this URL:
Ibrahim S, Rashed L. Correlation of urinary monocyte chemo-attractant protein-1 with other parameters of renal injury in type-II diabetes mellitus. Saudi J Kidney Dis Transpl [serial online] 2008 [cited 2021 Dec 6 ];19:911-917
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2008;volume=19;issue=6;spage=911;epage=917;aulast=Ibrahim;type=0