Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2008  |  Volume : 19  |  Issue : 6  |  Page : 933--936

Effect of intravenous ascorbic acid in hemodialysis patients with anemia and hypeferritinemia


Keyhanian Shahrbanoo1, Omolbanin Taziki2 
1 Department of Oncology, Azad University of Tonekabon, Ramsar, Iran
2 Department of Nephrology, Mazandaran University of Medical Science, Sari, Iran

Correspondence Address:
Omolbanin Taziki
Department of Nephrology, Mazandaran University of Medical Science, Sari
Iran

Hemodialysis (HD) patients with functional iron deficiency (FID) often develop resistance to recombinant human erythropoietin (Epo). The contributory role of chronic infla­mmation and oxidative stress in its pathogenesis is poorly understood. We assessed the effect of vitamin C, an antioxidant, on Epo-hyporesponsive anemia in hemodialysis patients with un­explained hyperferritinemia levels. Thirty-one of 132 with Hb < 11 g/dL were prospectively fo­llowed up after exclusion of reasons for Epo hyporesponsiveness. Patients were randomly divided into two groups: 15 patients received standard care and 300 mg of intravenous vitamin C with each dialysis session (group 1) and 15 patients received standard care (group 2). After 3 months, Hb and transferrin saturation levels significantly increased in group 1 but not in group 2 (p < 0.05%). Hemoglobin content in reticulocyte and serum ferritin decreased significantly in group 1 but not in control group. In conclusion, hemodialysis patients with refractory anemia and ade­quate iron stores, vitamin C improved responsiveness to Epo by augmenting iron mobilization and possibly via antioxidant effect.


How to cite this article:
Shahrbanoo K, Taziki O. Effect of intravenous ascorbic acid in hemodialysis patients with anemia and hypeferritinemia.Saudi J Kidney Dis Transpl 2008;19:933-936


How to cite this URL:
Shahrbanoo K, Taziki O. Effect of intravenous ascorbic acid in hemodialysis patients with anemia and hypeferritinemia. Saudi J Kidney Dis Transpl [serial online] 2008 [cited 2021 Jan 21 ];19:933-936
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2008;volume=19;issue=6;spage=933;epage=936;aulast=Shahrbanoo;type=0