Saudi Journal of Kidney Diseases and Transplantation

: 2009  |  Volume : 20  |  Issue : 3  |  Page : 362--369

Complement and hyper acute rejection

Mohammed WO Al-Rabia 
 Department of Hematology and Immunology, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

Correspondence Address:
Mohammed WO Al-Rabia
Department of Hematology and Immunology, College of Medicine, Umm Al-Qura University, Makkah
Saudi Arabia

Organ transplantation has been a major development in clinical medicine but its success has been marred by the immune system«SQ»s capacity to respond to «DQ»non-self«DQ» cells and tissues. A full molecular understanding of this mechanism and the myriad triggers for immune rejection is yet to be elucidated. Consequently, immunosuppressive drugs remain the mainstay of post-transplant ma­nagement; however, these interventions have side effects such as increased incidence of cancer, post-transplant lymphoproliferative disorders, susceptibility to infection if not managed appro­priately and the inconvenience to the patient of lifelong treatment. Novel therapeutic approaches based on molecular understanding of immunological processes are thus needed in this field. The notion that factors influencing successful transplants might be of use as therapeutic approaches is both scientifically and medically appealing. Recent developments in the understanding of successful transplants are expected to provide new opportunities for safer transplantation. This article reviews the present understanding of the molecular basis of rejection and the role of complement in this process as well as the possibility of generating «DQ»intelligent«DQ» therapy that better target crucial components of hyper­acute rejections.

How to cite this article:
Al-Rabia MW. Complement and hyper acute rejection.Saudi J Kidney Dis Transpl 2009;20:362-369

How to cite this URL:
Al-Rabia MW. Complement and hyper acute rejection. Saudi J Kidney Dis Transpl [serial online] 2009 [cited 2021 Jan 22 ];20:362-369
Available from:;year=2009;volume=20;issue=3;spage=362;epage=369;aulast=Al-Rabia;type=0