Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 21  |  Issue : 2  |  Page : 262--268

Clinical significance of N-Terminal Pro-B-type natriuretic peptide (NT-proBNP) in hemodialysis patients


Imed Helal1, Raja Belhadj2, Amira Mohseni2, Lilia Bazdeh3, Habiba Drissa3, Fethi ELyounsi1, Taieb Ben Abdallah1, Jaouida Abdelmoula2, Adel Kheder1 
1 Department of Nephrology (Pr Kheder), Charles Nicolle Hospital, Tunis, Tunisia
2 Department of Biochemical, Charles Nicolle Hospital, Tunis, Tunisia
3 Department of Cardiology, Charles Nicolle Hospital, Tunis, Tunisia

Correspondence Address:
Imed Helal
Department of Nephrology, Charles Nicolle Hospital, Boulevard 9, Avril1006, Tunis
Tunisia

Circulating biomarkers play a major role in the early detection of cardiovascular di­sease. The purpose of this study was to determine levels of N-Terminal Pro-B-type Natriuretic Pep­tide (NT-proBNP) in hemodialysis (HD) patients and to examine the relationship of this marker to left ventricular hypertrophy and to cardiac dysfunction. Plasma NT-proBNP concentrations were measured in patients undergoing chronic HD, who did not any clinical evidence of heart failure, (n=32; mean age 43.14 ± 12 years; sex-ratio 1.8) as well as healthy volunteers (n=32; mean age 45.84 ± 1.9 years; sex-ratio 1). In addition, the correlation between plasma NT-proBNP concentration and parameters of echocardiography was examined. The plasma NT-proBNP levels in the HD patients were significantly higher (14422.6 ± 13757.8 pg/mL) than those in healthy volunteers (39.21 pg/mL) (P< 10 -3 ). In addition, the area under the receiver operating characteristic curve (ROC) re­vealed that the cut-off level of NT-proBNP was 288 pg/mL. On univariate analysis, the plasma NT­proBNP concentrations, in patients on HD, correlated positively with age (P= 0.004; r=0.5), systolic (P= 0.046; r= 0.36) and diastolic blood pressures (P= 0.037; r= 0.37), residual diuresis (P= 0.09; r= 0.3), the left atrial diameter (LAD) (P= 0.006; r= 0.55), left ventricular mass index (LVMI) (P= 0.01; r= 0.44) and negatively with albumin (P= 0.01; r= -0.44). However, there was no correlation bet­ween plasma levels of NT-proBNP and gender, body mass index (BMI), mean period on dialysis, pulse pressure, dry weight and left ventricular dysfunction. On multivariate analysis, only age (P= 0.014, RR= 2.8) was associated with significantly increased levels of NT-proBNP. Further studies are needed to carefully assess the diagnostic accuracy and prognostic value of NT-proBNP in patients on HD.


How to cite this article:
Helal I, Belhadj R, Mohseni A, Bazdeh L, Drissa H, ELyounsi F, Abdallah TB, Abdelmoula J, Kheder A. Clinical significance of N-Terminal Pro-B-type natriuretic peptide (NT-proBNP) in hemodialysis patients.Saudi J Kidney Dis Transpl 2010;21:262-268


How to cite this URL:
Helal I, Belhadj R, Mohseni A, Bazdeh L, Drissa H, ELyounsi F, Abdallah TB, Abdelmoula J, Kheder A. Clinical significance of N-Terminal Pro-B-type natriuretic peptide (NT-proBNP) in hemodialysis patients. Saudi J Kidney Dis Transpl [serial online] 2010 [cited 2020 Dec 4 ];21:262-268
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2010;volume=21;issue=2;spage=262;epage=268;aulast=Helal;type=0