Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 21  |  Issue : 5  |  Page : 863--866

Hyperhemocysteinemia and cardiovascular risks in hemodialysis patients


Mohammad Mahdi Sagheb, Mohammad Ali Ostovan, Zahra Sohrabi, Elham Atabati, Ghanbar Ali Raisjalai, Jamshid Roozbeh 
 Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Zahra Sohrabi
Shiraz University of Medical Sciences, Shiraz
Iran

The risk of premature and progressive occlusive vascular disease is high in chronic uremic patients, and it accounts for more than 40% of the mortality in dialysis patients. End stage renal failure (ESRF) patients exhibit elevated plasma homocystein levels, about four fold as much as those in the controls, and it is now considered as a causative factor for increased risk of cardiovascular death among these patients. The aim of this study was to evaluate the relationship of total plasma homocysteine level and echocardiographic abnormalities as a surrogate of cardiac disease outcome in hemodialysis patients. 123 adult patients on maintenance hemodialysis and having echocardiography done during January till November 2006 were enrolled in this cross­sectional study. Plasma homocysteine level was directly related to the presence of aortic regur­gitation r= 0.27 P= 0.009. There were negative correlations between ejection fraction (EF), left ventricular systolic dimension (LV.S) (r= - 0.71, P= 0.0001), left ventricular diastolic dimension (LV.D) (r= -0.23 p= 0.01) and age (r= - 0.021 P= 0.02). In conclusion we did not find the para­doxical reverse epidemiology in our patients and plasma total homocysteine level was in direct correlation with cardiac risk factors such as left ventricular mass index and aortic regurgitation.


How to cite this article:
Sagheb MM, Ostovan MA, Sohrabi Z, Atabati E, Raisjalai GA, Roozbeh J. Hyperhemocysteinemia and cardiovascular risks in hemodialysis patients.Saudi J Kidney Dis Transpl 2010;21:863-866


How to cite this URL:
Sagheb MM, Ostovan MA, Sohrabi Z, Atabati E, Raisjalai GA, Roozbeh J. Hyperhemocysteinemia and cardiovascular risks in hemodialysis patients. Saudi J Kidney Dis Transpl [serial online] 2010 [cited 2021 Apr 21 ];21:863-866
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2010;volume=21;issue=5;spage=863;epage=866;aulast=Sagheb;type=0