Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 21  |  Issue : 5  |  Page : 872--875

Surrogate markers of subtle renal injury in patients with visceral leishmaniasis


NAA Elnojomi, AM Musa, BM Younis, MEE Elfaki, AM El-Hassan, EAG Khalil 
 The Leishmaniasis Research Group/Sudan, The Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

Correspondence Address:
EAG Khalil
Department of Clinical Pathology and Immunology, Institute of Endemic Diseases, University of Khartoum, Khartoum
Sudan

Sudanese Visceral Leishmaniasis (VL) is a disease of children that is characterized by fever, hepatosplenomegaly, lymphadenopathy, pancytopenia, and renal injury. Microalbumi­nuria (MA) and urinary retinol binding protein (urRBP) are useful markers for glomerular and tubular dysfunctions, respectively. We report the prevalence of subtle renal injury in 88 para­sitologically confirmed VL patients in a cross-sectional and hospital-based study. Blood and urine were collected before treatment for hematological, biochemical profiles in addition to MA and urRBP measurement using competitive solid phase, sandwich enzyme-linked immune sorbent assay (ELISA), and immunoturbidometry. All the patients had normal serum urea and creatinine levels and no detectable urRBP. However, 40% of the patients had MA detected by ELISA, and 42% were reactive with turbidometry. The sensitivity, specificity, positive and negative predictive values for MA turbidometric technique were calculated as 100%; 96%; 95% and 100%, res­pectively. In conclusion; subtle renal injury in VL is mainly glomerular. Turbidometry for MA measurement is a simple, inexpensive, sensitive, and specific technique with high predictive values.


How to cite this article:
Elnojomi N, Musa A M, Younis B M, Elfaki M, El-Hassan A M, Khalil E. Surrogate markers of subtle renal injury in patients with visceral leishmaniasis.Saudi J Kidney Dis Transpl 2010;21:872-875


How to cite this URL:
Elnojomi N, Musa A M, Younis B M, Elfaki M, El-Hassan A M, Khalil E. Surrogate markers of subtle renal injury in patients with visceral leishmaniasis. Saudi J Kidney Dis Transpl [serial online] 2010 [cited 2021 Jan 23 ];21:872-875
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2010;volume=21;issue=5;spage=872;epage=875;aulast=Elnojomi;type=0