Saudi Journal of Kidney Diseases and Transplantation

CASE REPORT
Year
: 2010  |  Volume : 21  |  Issue : 5  |  Page : 919--922

Porphyria cutanea tarda in a chronic hemodialysis patient


Jannet Labidi 
 Department of Internal Medicine, Hospital Militaire Principal d'instruction, Tunis, Tunisia

Correspondence Address:
Jannet Labidi
Department of Internal Medicine, Hospital Militaire Principal d«SQ»instruction, Tunis
Tunisia

End-stage renal failure and long-term hemodialysis (HD) treatment promote the development of genetically conditioned porphyria cutanea tarda (PCT). Iron overload is often asso­ciated with this disease and is thought to play a role in its pathogenesis. We report a case of HD­related PCT, which improved with deferoxamine treatment. A 33-year-old woman, with end-stage renal failure on HD since 1998, presented with a history of blisters on the face and dorsum of the hands, of several months duration. Laboratory analysis showed: hemoglobin 10.4 g/dL; a moderate hepatic cytolysis; ferritin 1300 μg/L (Nl: 8-120 μg/L) and negative serology for HIV, HBV and HCV. Porphyrin analyses showed a PCT pattern. Skin biopsy findings and direct immunofluo­rescence were consistent with PCT. The patient received deferoxamine (40 mg/kg intravenously every week for 6 weeks) which led to dramatic improvement of the symptoms. Several treatments are proposed in the management of dialysis-related PCT. This case confirms that deferoxamine can induce rapid and prolonged remission.


How to cite this article:
Labidi J. Porphyria cutanea tarda in a chronic hemodialysis patient.Saudi J Kidney Dis Transpl 2010;21:919-922


How to cite this URL:
Labidi J. Porphyria cutanea tarda in a chronic hemodialysis patient. Saudi J Kidney Dis Transpl [serial online] 2010 [cited 2021 Apr 11 ];21:919-922
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2010;volume=21;issue=5;spage=919;epage=922;aulast=Labidi;type=0