Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 21  |  Issue : 6  |  Page : 1058--1065

The reno-protective effect of aqueous extract of Carum carvi (black zeera) seeds in streptozotocin induced diabetic nephropathy in rodents


Soban Sadiq1, Abdul Hannan Nagi2, Muhammad Shahzad1, Azam Zia3 
1 Department of Pharmacology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, Pakistan
2 Department of Pathology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore, Pakistan
3 Department of Pharmacology, Rawalpindi Medical College, Rawalpindi, Pakistan

Correspondence Address:
Soban Sadiq
House No. 526, Main Hill View Lane, Sector 2, Near Rehmat Manzil, Adiala Road, Rawalpindi
Pakistan

To assess the effect of aqueous extract of Carum carvi seeds in experimentally induced diabetic nephropathy (DN) in rodents, we studied 48 adult male Wistar rats divided into 4 groups: normal controls (group A), diabetes positive control (group B), and experimental (groups C and D). They received Carum carvi extract as a renoprotective agent. Rats having fasting blood glucose levels over 280 mg/dL were included in this study. Group C rats received STZ (60 mg/kg) and aqueous extract of Carum carvi at 30 mg/kg of body weights. On the other hand group D rats received STZ (60 mg/kg) and aqueous extract of Carum carvi at 60 mg/kg of body weight. Blood samples were collected on the 60 th day, and kidneys were also extracted for examination. The diabetic group rats showed a variable increase in the serum levels of glucose, urea, creatinine, total urinary protein and microalbuminuric levels. Body weight decreased and urine volume increased in the diabetic groups. 30 mg/kg body weight of Carum carvi dose decreased the levels of these parameters in rats. On the other hand, 60 mg/kg body weight of Carum carvi dose significantly decreased the levels of the biochemical parameters. The morphological examination of group C rats showed no changes whereas the rats in group D showed moderate changes. Carum carvi constituents, especially flavonoids and carvone have strong anti-oxidant activity, which provides reno-protection against diabetes and its complications. In conclusion, high dose of Carum carvi aqueous seeds extract (60 mg/kg) showed reno-protection against STZ induced dia­betic nephropathy in rats.


How to cite this article:
Sadiq S, Nagi AH, Shahzad M, Zia A. The reno-protective effect of aqueous extract of Carum carvi (black zeera) seeds in streptozotocin induced diabetic nephropathy in rodents.Saudi J Kidney Dis Transpl 2010;21:1058-1065


How to cite this URL:
Sadiq S, Nagi AH, Shahzad M, Zia A. The reno-protective effect of aqueous extract of Carum carvi (black zeera) seeds in streptozotocin induced diabetic nephropathy in rodents. Saudi J Kidney Dis Transpl [serial online] 2010 [cited 2021 Oct 26 ];21:1058-1065
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2010;volume=21;issue=6;spage=1058;epage=1065;aulast=Sadiq;type=0