Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 24  |  Issue : 4  |  Page : 731--736

Urinary endothellin-1 level in children with pyelonephritis and hydronephrosis


Mostafa Sharifian, Mitra Ahmadi, Abdollah Karimi, Ranna Esmaili Zand, Roozbeh Moghadar, Roya Ahmadi, Masoud Dadkhah Chimeh 
 Pediatric Infections Research Center (PIRC), Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

Correspondence Address:
Mostafa Sharifian
Mofid Hospital, Shariati Street, Tehran
IR Iran

Hydronephrosis is a common finding in patients with urinary tract infection (UTI). Endothellin-1 (ET-1) is a potent vasoactive peptide that has vasoconstrictive effects. It has been shown that urinary ET-1 increases in urinary obstructions. In this study, we measured the urinary ET-1 level in patients with UTI and hydronephrosis of various causes. In this case-control study, we evaluated the urinary ET-1 level in 45 patients who had UTI and hydronephrosis, serving as a case group, and 45 patients who had UTI without hydronephrosis, serving as a control group. Urinary ET-1 was quantified using enzyme-linked immunosorbent assay and urinary creatinine (Cr) by Jaffe method. To rule out the effect of urinary flow rate, the urinary ET-1 to Cr correlation was considered for analysis of the results. The mean age of the patients in the case and control groups was 36.5 ± 27.2 and 26.2 ± 15.5 months, respectively (P >0.01). The mean urinary ET-1 was 89.6 ± 41.7 pg/dL in the case group and 29.3 ± 26 pg/dL in the control group, P <0.001. The mean urinary ET-1 was 121 ± 55.4 pg/dL in patients who had grade 4 hydronephrosis. We conclude that urinary ET-1 was significantly higher in the obstructed than in non-obstructed cases. Urinary ET-1 could be a useful marker that can be utilized in young children for diagnosis of hydronephrosis, especially obstructive cases.


How to cite this article:
Sharifian M, Ahmadi M, Karimi A, Zand RE, Moghadar R, Ahmadi R, Chimeh MD. Urinary endothellin-1 level in children with pyelonephritis and hydronephrosis.Saudi J Kidney Dis Transpl 2013;24:731-736


How to cite this URL:
Sharifian M, Ahmadi M, Karimi A, Zand RE, Moghadar R, Ahmadi R, Chimeh MD. Urinary endothellin-1 level in children with pyelonephritis and hydronephrosis. Saudi J Kidney Dis Transpl [serial online] 2013 [cited 2020 Dec 3 ];24:731-736
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2013;volume=24;issue=4;spage=731;epage=736;aulast=Sharifian;type=0