Saudi Journal of Kidney Diseases and Transplantation

RENAL DATA FROM THE ARAB WORLD
Year
: 2013  |  Volume : 24  |  Issue : 4  |  Page : 825--831

Effect of relative hypoparathyroidism on the responsiveness to recombinant human erythropoietin in chronic hemodialysis patients: A single Saudi center experience


Khalid Al Saran1, Alaa Sabry2, Ashraf H Hassan3 
1 Prince Salman Center for Kidney Diseases, Riyadh, Kingdom of Saudi Arabia
2 Nephrology Division, Urology and Nephrology Center, Mansoura University, Egypt
3 Internal Medicine Department, Mansoura University, Egypt

Correspondence Address:
Alaa Sabry
Mansoura Urology and Nephrology Center, Mansoura University
Egypt

Anemia is a common concomitant disorder in dialysis patients. The responsiveness to recombinant human erythropoietin in hemodialysis (HD) patients with relative hypoparathyroidism [4 ≤ intact parathyroid hormone (iPTH) ≤16.5 pmol/L] remains undetermined. We retrospectively studied 70 chronic hemodialysis patients who were divided into two groups: Group A (32 patients) had 16.5 ≤ iPTH levels <33.5 pmol/L and Group B (38 patients) had 4 ≥ iPTH≤16.5 pmol/L during the preceding six months without 1- (OH) Vitamin D3 administration. The percentage of female gender was significantly higher in Group B compared with Group A (P = 0.018). In Groups A and B, the mean weekly recombinant human erythropoietin dose (U/kg/ week) was 227.96 ± 95.24 vs. 154.1 ± 84.9 (P = 0.001) and the mean hemoglobin level was 11.15 ± 0.63 g/dL versus 11.62 ± 0.63 g/dL (P = 0.008). There was no significant statistical difference regarding the other biochemical markers (serum ferritin, iron saturation, serum Ca, serum alkaline phosphatase, C-reactive protein, serum B12, serum folate levels, residual renal function and Kt/v) between the groups. If other factors related to anemia are excluded in chronic HD patients, the lower the iPTH level (relative hypoparathyroidism) the better the responsiveness to recombinant human erythropoietin.


How to cite this article:
Al Saran K, Sabry A, Hassan AH. Effect of relative hypoparathyroidism on the responsiveness to recombinant human erythropoietin in chronic hemodialysis patients: A single Saudi center experience.Saudi J Kidney Dis Transpl 2013;24:825-831


How to cite this URL:
Al Saran K, Sabry A, Hassan AH. Effect of relative hypoparathyroidism on the responsiveness to recombinant human erythropoietin in chronic hemodialysis patients: A single Saudi center experience. Saudi J Kidney Dis Transpl [serial online] 2013 [cited 2021 Jun 24 ];24:825-831
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2013;volume=24;issue=4;spage=825;epage=831;aulast=Al;type=0