Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 26  |  Issue : 1  |  Page : 26--33

Relationship between asymmetric dimethylarginine plasma level and left ventricular mass in hemodialysis patients


Yasser El Shahawy1, Yasser Soliman1, Ahmed Rifaie2, Howayda Shenawy1, Maha Behairy1, Gamal Mady1 
1 Nephrology Unit, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Dr. Yasser El Shahawy
Nephrology Unit, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo
Egypt

Left ventricular hypertrophy (LVH) and left ventricular dysfunction are highly prevalent in patients with end-stage renal disease (ESRD). Several studies suggest that left ventricular mass and function is strongly modulated by the nitric oxide (NO) system. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial-based NO synthase, is emerging as an important cardiovascular risk factor in ESRD patients. Our objective is to evaluate the relationship between plasma ADMA level and LVH among hemodialysis (HD) patients. Plasma ADMA measurements by enzyme-linked immunesorbent assay and echocardiographic evaluation were performed for 40 patients on regular HD, 20 patients with pre-dialysis chronic kidney disease, 20 hypertensive patients with left ventricular hypertrophy and normal kidney function and 20 healthy age and sex-matched subjects as a control group. Residual renal function (RRF) was measured in HD patients by urea clearance from a urine collection. Mean values of plasma ADMA level were significantly high in all patient groups when compared with the control group (P < 0.001). However, there was no significant difference between groups I, II and III as regards mean values of plasma ADMA (P >0.05) and between ADMA and RRF in HD patients (r = -0.20, P = 0.60). It was also seen that plasma ADMA was not correlated with left ventricular mass index; however, there could be an association between ADMA level and diastolic dysfunction. The plasma ADMA level was found to be high in the three studied patient groups in comparison with the control group. HD is not an effective procedure for adequate removal of ADMA.


How to cite this article:
El Shahawy Y, Soliman Y, Rifaie A, Shenawy H, Behairy M, Mady G. Relationship between asymmetric dimethylarginine plasma level and left ventricular mass in hemodialysis patients.Saudi J Kidney Dis Transpl 2015;26:26-33


How to cite this URL:
El Shahawy Y, Soliman Y, Rifaie A, Shenawy H, Behairy M, Mady G. Relationship between asymmetric dimethylarginine plasma level and left ventricular mass in hemodialysis patients. Saudi J Kidney Dis Transpl [serial online] 2015 [cited 2021 Apr 20 ];26:26-33
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2015;volume=26;issue=1;spage=26;epage=33;aulast=El;type=0