Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 26  |  Issue : 6  |  Page : 1130--1134

Predictive factors for increased aortic pulse wave velocity in renal transplant recipients and its relation to graft outcome


Muazam Ayub, Kifayat Ullah, Imtiaz Masroor, Ghias Uddin Butt 
 Department of Nephrology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan

Correspondence Address:
Kifayat Ullah
Department of Nephrology, Pakistan Institute of Medical Sciences, Islamabad
Pakistan

To evaluate aortic stiffness in renal transplant patients and to determine the correlation of renal insufficiency and estimated glomerular filtration rate (eGFR) with aortic pulse wave velocity (APWV), we studied 96 renal transplant patients followed-up at our center. We measured the APWV using transcutaneous Doppler flow recordings and the foot-to-foot method, and calculated the eGFR using the Modification of Diet in Renal Disease equation. The study included 81 (84.4%) males and 15 (15.6%) females. The mean age of the patients was 37.84 ± 10.10 years. The mean duration of transplant was 47.90 ± 34.40 months. The eGFR of the patients ranged from 1 to 120 mL/min, with a mean GFR of 72.6 ± 23.2 mL/min. Sixty-seven (69.8%) patients had eGFR > 60 mL/min and hence had stages 1 and 2 chronic kidney disease (CKD), 27 (28.1%) patients had eGFR 30-60 mL/min and hence had stage 3 CKD and two (2.1%) patients had eGFR <30 mL/min and hence had stages 4 and 5 CKD. The APWV of the patients ranged from 4 to 14.2 m/s, with a mean of 7.49 ± 2.47 m/s. A significant inverse correlation was found between the APWV and eGFR (Pearson correlation coefficient, -0.427, P = 0.00). The mean APWV was significantly higher among patients with higher CKD stage, P = 0.004. We conclude that the APWV is related to the renal graft dysfunction as measured by eGFR. The poorer the renal function, the higher was the APWV. Determination of the APWV may be helpful in predicting the outcome in renal transplant recipients.


How to cite this article:
Ayub M, Ullah K, Masroor I, Butt GU. Predictive factors for increased aortic pulse wave velocity in renal transplant recipients and its relation to graft outcome.Saudi J Kidney Dis Transpl 2015;26:1130-1134


How to cite this URL:
Ayub M, Ullah K, Masroor I, Butt GU. Predictive factors for increased aortic pulse wave velocity in renal transplant recipients and its relation to graft outcome. Saudi J Kidney Dis Transpl [serial online] 2015 [cited 2022 Jan 19 ];26:1130-1134
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2015;volume=26;issue=6;spage=1130;epage=1134;aulast=Ayub;type=0