Saudi Journal of Kidney Diseases and Transplantation

RENAL DATA FROM ASIA-AFRICA
Year
: 2019  |  Volume : 30  |  Issue : 3  |  Page : 686--693

A study of prevalence and correlates of nonadherence to immunosuppressive medications in renal transplant recipients of South Indian population and their impact on long-term graft function


Karunamoorthy Saravanakumar, Avinash Prakash, Balasubramaniyan Thopalan, Jeyachandran Dhanapriya, Dineshkumar Thanigachalam, Sakthirajan Ramanathan, Natarajan Gopalakrishnan 
 Institute of Nephrology, Madras Medical College, Chennai, Tamil Nadu, India

Correspondence Address:
Avinash Prakash
Institute of Nephrology, Madras Medical College, Chennai, Tamil Nadu
India

Nonadherence to immunosuppressant medications leading onto poor graft outcome is frequent among renal transplant recipients. In this study, we sought to assess the prevalence and correlates of nonadherence to immunosuppressants and its impact on graft function. A singlecenter, retrospective cum cross-sectional study of renal transplant recipients of age >18 years and who had completed at least six months after transplantation was performed. Nonadherence was assessed based on the Immunosuppressant Therapy Adherence Scale questionnaire. Factors attributed to nonadherence were assessed based on the Immunosuppressant Therapy Barriers Scale (ITBS) questionnaire. Social, economic, demographic data, and all transplant related information were recorded. Two hundred and seventy-nine patients were included in the study, of whom 78% were male. Median follow-up period was 46 months (interquartile range – 24 months to 82 months). Seventy-four patients (26.5%) admitted nonadherence to immunosuppressants. The nonadherence was significantly related to the male gender, late acute rejection episodes, rise in serum creatinine from > 0.5 mg/dL from nadir level, lower blood levels of calcineurin inhibitor, and higher ITBS scores. Refill rates and use of alarm reminders were not significantly associated with better adherence.


How to cite this article:
Saravanakumar K, Prakash A, Thopalan B, Dhanapriya J, Thanigachalam D, Ramanathan S, Gopalakrishnan N. A study of prevalence and correlates of nonadherence to immunosuppressive medications in renal transplant recipients of South Indian population and their impact on long-term graft function.Saudi J Kidney Dis Transpl 2019;30:686-693


How to cite this URL:
Saravanakumar K, Prakash A, Thopalan B, Dhanapriya J, Thanigachalam D, Ramanathan S, Gopalakrishnan N. A study of prevalence and correlates of nonadherence to immunosuppressive medications in renal transplant recipients of South Indian population and their impact on long-term graft function. Saudi J Kidney Dis Transpl [serial online] 2019 [cited 2020 Oct 22 ];30:686-693
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2019;volume=30;issue=3;spage=686;epage=693;aulast=Saravanakumar;type=0