Saudi Journal of Kidney Diseases and Transplantation

RENAL DATA FROM ASIA–AFRICA
Year
: 2020  |  Volume : 31  |  Issue : 3  |  Page : 647--654

Seroprevalence of Hepatitis B, C and coinfection among patients with chronic kidney disease in a Nigerian hospital


Adeyemi Ogunleye1, Tosin T Oluwafemi1, Akinwumi A Akinbodewa2, Victoria O Daomi1, Oluseyi A Adejumo2, Temitope C Omisakin3 
1 Department of Medical Laboratory Services, University of Medical Science Teaching Hospital, Ondo, Ondo State, Nigeria
2 Department of Medicine, University of Medical Science Teaching Hospital, Ondo, Ondo State, Nigeria
3 Department of Hematology, Federal Medical Centre, Ido-Ekiti, Ekiti State, Nigeria

Correspondence Address:
Adeyemi Ogunleye
Medical Laboratory Services, University of Medical Science Teaching Hospital, Ondo, Ondo State
Nigeria

Infectious diseases remain a major health challenge in developing countries, compounding the woes of growing noncommunicable diseases such as chronic kidney disease (CKD). Increased morbidity and mortality have been reported among CKD patients with hepatitis infection and may necessitate protocol for treatment, follow-up, and prevention of spread. We aimed to determine the prevalence of viral hepatitis B and C infections among CKD patients and the effects on their liver enzymes. In this retrospective study, 314 CKD patients screened for hepatitis C virus (HCV) and hepatitis B surface antigen (HBsAg) were reviewed. Participants were screened at the time of diagnosis of CKD or referral, using qualitative enzyme immunoassay rapid test kits before the initiation of treatment. Individuals who were reactive to human immunodeficiency virus were excluded, and data were analyzed using IBM SPSS Statistics version 21.0. Participants included 206 males (65.6%) and 108 females (34.4%), with a mean age of 50.5 ± 16.3 years. The seroprevalence of HBsAg, HCV, and coinfection was seen in 15.6% (49), 4.8% (15), and 0.92% of the patients, respectively. More than half (63.6%) of the seropositive patients were below 50 years of age. Alanine transaminase (ALT) activity was higher in HCV seropositive than negative (10.5 ± 10.5 vs. 21.2 ± 35.9) (P = 0.001), while aspartate transaminase (AST) and alkaline phosphatase (ALP) were similar. ALT, AST, and ALP were also similar between HBsAg-seropositive and HBsAg-negative patients. The prevalence of hepatitis B and C is high among our CKD patients. This suggests the need for improved screening and treatment of hepatitis infection in this group. Immunization may also be essential to prevent its spread among patients requiring hemodialysis.


How to cite this article:
Ogunleye A, Oluwafemi TT, Akinbodewa AA, Daomi VO, Adejumo OA, Omisakin TC. Seroprevalence of Hepatitis B, C and coinfection among patients with chronic kidney disease in a Nigerian hospital.Saudi J Kidney Dis Transpl 2020;31:647-654


How to cite this URL:
Ogunleye A, Oluwafemi TT, Akinbodewa AA, Daomi VO, Adejumo OA, Omisakin TC. Seroprevalence of Hepatitis B, C and coinfection among patients with chronic kidney disease in a Nigerian hospital. Saudi J Kidney Dis Transpl [serial online] 2020 [cited 2021 Mar 6 ];31:647-654
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2020;volume=31;issue=3;spage=647;epage=654;aulast=Ogunleye;type=0