Saudi Journal of Kidney Diseases and Transplantation

CASE REPORT
Year
: 2020  |  Volume : 31  |  Issue : 5  |  Page : 1106--1109

Leukocytoclastic Vasculitis Associated with Bortezomib Therapy


Thiagarajan Raj Yashwanth, Raveendran Vairakkani, Nagalakshmi Dhanapal Srinivasaprasad, Suren Sujith, Kaliaperumal Thirumalvalavan, Mervin Edwin Fernando 
 Department of Nephrology, Government Stanley Medical College, Chennai, Tamil Nadu, India

Correspondence Address:
Raveendran Vairakkani
Department of Nephrology, Government Stanley Medical College, Chennai, Tamil Nadu
India

A 28-year-old male, 10 years post live-related renal transplant with stable graft function of 1.4 mg/dL, presented with complaints of loss of appetite and vomiting for three days. On evaluation, he was found to have significant graft dysfunction with a creatinine of 10.3 mg/dL. He was initiated on hemodialysis in view of uremic gastrointestinal symptoms. Graft biopsy done revealed acute cell-mediated rejection BANFF IIB and diffuse C4d-positive antibody-mediated rejection. He was treated with intravenous methylprednisolone, therapeutic plasma exchange, and intravenous immunoglobulin therapy, following which his graft function improved gradually. He received multiple injections of bortezomib as a part of anti-rejection treatment protocol and developed peripheral neuropathy, leukocytoclastic vasculitis, and varicellosis. This case report is to highlight the unusual phenomenon of leukocytoclastic vasculitis in a post renal transplant setting secondary to bortezomib therapy.


How to cite this article:
Yashwanth TR, Vairakkani R, Srinivasaprasad ND, Sujith S, Thirumalvalavan K, Fernando ME. Leukocytoclastic Vasculitis Associated with Bortezomib Therapy.Saudi J Kidney Dis Transpl 2020;31:1106-1109


How to cite this URL:
Yashwanth TR, Vairakkani R, Srinivasaprasad ND, Sujith S, Thirumalvalavan K, Fernando ME. Leukocytoclastic Vasculitis Associated with Bortezomib Therapy. Saudi J Kidney Dis Transpl [serial online] 2020 [cited 2021 Sep 28 ];31:1106-1109
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2020;volume=31;issue=5;spage=1106;epage=1109;aulast=Yashwanth;type=0