Year : 2020 | Volume
: 31 | Issue : 6 | Page : 1198--1205
Urinary podocalyxin: Is it a real index of disease activity in egyptian patients lupus nephritis?
Ahmed Fayed1, Mahmoud M Elnokeety1, Mohamed Elyamny1, Hany Hammad1, Dina Hesham Ahmed Soliman2, Reham Abdelghany Ahmed1
1 Department of Internal Medicine, Nephrology Unit, School of Medicine, Cairo University, Cairo, Egypt
2 Department of Chemical Pathology, School of Medicine, Cairo University, Cairo, Egypt
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease characterized by production of a number of antinuclear antibodies. Podocyte injury is an important feature and can be detected by several markers including podocalyxin. We aimed to evaluate the impact of SLE on urinary levels of podocalyxin and to determine its relationship to renal biopsy, proteinuria, and disease activity in lupus nephritis (LN) patients. Sixty individuals were recruited; 30 SLE patients with LN as well as 30 healthy volunteers and they were subjected to full history, clinical examination, kidney function, protein/creatinine ratio, urinary podocalyxin, and kidney biopsy. Patients with LN had higher level of urinary podocalyxin (3.96 ± 2.24) than the other group (0 ± 0), (P <0.001). Class IV LN was the most common class found among LN patients [18 cases (60%)]. There was a statistically significant positive correlation between SLE disease activity index score, protein/creatinine ratio, and urinary podocalyxin (P <0.001, r = 0.98) (P <0.001, r = 0.765). There was a statistically significant negative correlation between serum albumin, serum calcium, and urinary podocalyxin (P = 0.001, r = -0.589) (P = 0.025, r = -0.407). Urinary podocalyxin level significantly predicts the pathological impact of SLE on the kidney and could be used as a noninvasive marker for such effect and its progression.
Department of Internal Medicine, Nephrology Unit, School of Medicine, Cairo University, Cairo
|How to cite this article:|
Fayed A, Elnokeety MM, Elyamny M, Hammad H, Soliman DH, Ahmed RA. Urinary podocalyxin: Is it a real index of disease activity in egyptian patients lupus nephritis?.Saudi J Kidney Dis Transpl 2020;31:1198-1205
|How to cite this URL:|
Fayed A, Elnokeety MM, Elyamny M, Hammad H, Soliman DH, Ahmed RA. Urinary podocalyxin: Is it a real index of disease activity in egyptian patients lupus nephritis?. Saudi J Kidney Dis Transpl [serial online] 2020 [cited 2021 Jun 22 ];31:1198-1205
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2020;volume=31;issue=6;spage=1198;epage=1205;aulast=Fayed;type=0