Saudi Journal of Kidney Diseases and Transplantation

RENAL DATA FROM ASIA–AFRICA
Year
: 2021  |  Volume : 32  |  Issue : 1  |  Page : 204--208

Clinical and Histopathological Profile of Adolescent onset Idiopathic Nephrotic Syndrome in North Indian Children


Kanika Kapoor1, Abhijeet Saha2, Nand Kishore Dubey3, Vinita Vijay Batra4, Ashish Dutt Upadhyay5 
1 Department of Pediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
2 Department of Pediatrics, Division of Pediatric Nephrology, Lady Hardinge Medical College and Kalawati Saran Children’s Hospital, New Delhi, India
3 Department of Pediatrics, Postgraduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, India
4 Department of Pathology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India
5 Department of Biostatistics, All India Institute of Medical Science, New Delhi, India

Correspondence Address:
Abhijeet Saha
Department of Pediatrics, Division of Pediatric Nephrology, Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi
India

Adolescent onset idiopathic nephrotic syndrome (INS) is marked by increased incidence atypical features and non-minimal change disease in histopathology. The objective of the study was to analyze the clinical features and histopathological spectrum of adolescent-onset INS. It was conducted in a Pediatric nephrology clinic of a tertiary care hospital in North India. We retrospectively evaluated clinical features, biochemical investigations and histopathology of 33 adolescents with idiopathic NS registered in pediatric nephrology clinic. Twenty-three (70.0%) adolescents had steroid resistant nephrotic syndrome. Hematuria was present in 39%, hypertension 36% and acute kidney injury (AKI) in 27%. Three-fourth of adolescents who underwent biopsy had non-minimal change disease in histopathology. Adolescent onset INS have increased incidence of AKI, hypertension, and non-minimal change disease.


How to cite this article:
Kapoor K, Saha A, Dubey NK, Batra VV, Upadhyay AD. Clinical and Histopathological Profile of Adolescent onset Idiopathic Nephrotic Syndrome in North Indian Children.Saudi J Kidney Dis Transpl 2021;32:204-208


How to cite this URL:
Kapoor K, Saha A, Dubey NK, Batra VV, Upadhyay AD. Clinical and Histopathological Profile of Adolescent onset Idiopathic Nephrotic Syndrome in North Indian Children. Saudi J Kidney Dis Transpl [serial online] 2021 [cited 2021 Sep 25 ];32:204-208
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2021;volume=32;issue=1;spage=204;epage=208;aulast=Kapoor;type=0