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 Indian J Med Microbiol  
 

Figure 1. Control of glomerular filtration rate (GFR) in the neonate. A. glomerular capillary pressure (GCP) is maintained by greter angiotensin II vasoconstriction at the efferent (e) than afferent (a) arteriole, but the effects are attenuated by concurret vasodilation mediated by prostaglandins (PG) B. Angiotensin converting enzyme igiitors (CEI) such as captopril allow unopposed vasodilation by prostaglandins, thereby reducing GCP and GFR. C. Indomethacin (INDO) reduces prostatglandin synthesis, thereby allowing unopposed angiotensin II-mediated, vasoconstriction, resulting in reduced glomerular blood flow (GBW) and decreased GFR. From reference (40) with permission

Figure 1. Control of glomerular filtration rate (GFR) in the neonate. A. glomerular capillary pressure (GCP) is maintained by greter angiotensin II vasoconstriction at the efferent (e) than afferent (a) arteriole, but the effects are attenuated by concurret vasodilation mediated by prostaglandins (PG) B. Angiotensin converting enzyme igiitors (CEI) such as captopril allow unopposed vasodilation by prostaglandins, thereby reducing GCP and GFR. C. Indomethacin (INDO) reduces prostatglandin synthesis, thereby allowing unopposed angiotensin II-mediated, vasoconstriction, resulting in reduced glomerular blood flow (GBW) and decreased GFR. From reference (40) with permission