Figure 2. The rate of progression in children with chronic kidney insufficiency and renal osteodystrophy Treatment with 1,25 dihydroxyvitamin D (Calcitriol) demonstrated a three-fold faster rate of deterioration (shown in solid lines) compared to dihydrotachysterol treatment (shown in interrupted lines), in a double-blinded, randomized, controlled clinical trial. From Chan JCM, Chinchilli VM, McEnery PT, Abitbol CL, Boineau FG, Friedman AL., et al. Controlled clinical trial Growth Failure in Children with Chronic Renal Insuffi-ciency and the effectiveness of calcitriol versus dihydrotachysterol. J Pediatr 1994;124:520-528. [By permission of Mosby Co.].